Cytarabine and daunorubicin (liposomal): Uses, Side Effects & Warnings

Generic name: cytarabine and daunorubicin (liposomal) [ sye-tar-a-been-and-daw-noe-roo-bi-sin ]

Drug class: Antineoplastic combinations

Dosage form: intravenous powder for injection (100 mg-44 mg)

Pregnancy & Lactation: Risk data available

What is Cytarabine and daunorubicin (liposomal)?

Cytarabine and daunorubicin liposomal is a combination medicine used to treat acute myeloid leukemia that is newly diagnosed in adults and children at least 1 year old.

Cytarabine and daunorubicin liposomal may also be used for purposes not listed in this medication guide.

Warnings

cytarabine and daunorubicin can make it easier for you to bleed. Contact your doctor or seek emergency medical attention if you have easy bruising, unusual bleeding, or any bleeding that will not stop. You may also have bleeding on the inside of your body, such as in your stomach or intestines, or in your brain.

Call your doctor at once if you have: signs of bleeding in your digestive tract--feeling very weak or dizzy, severe stomach pain, black or bloody stools, or if you cough up blood or vomit that looks like coffee grounds; or signs of bleeding in the brain--sudden numbness or weakness (especially on one side of the body), sudden severe headache, or problems with vision or balance.

Before Taking

You should not be treated with this medicine if you are allergic to cytarabine or daunorubicin.

Tell your doctor if you have ever had:

• heart disease;

• liver or kidney disease;

• radiation treatment of your chest area; or

• Wilson's disease (a rare genetic disorder).

You may need to have a negative pregnancy test before starting this treatment.

Both men and women using this medicine should use effective birth control to prevent pregnancy. Cytarabine and daunorubicin liposomal can harm an unborn baby if the mother or father is using this medicine.

Keep using birth control for at least 6 months after your last dose. Tell your doctor right away if a pregnancy occurs while either the mother or the father is using this medicine.

It may be harder for you to get a woman pregnant while you are using this medicine. You should still use birth control to prevent pregnancy because the medicine can harm an unborn baby.

You should not breastfeed while using this medicine and for at least 2 weeks after your last dose.

How should I use Cytarabine and daunorubicin (liposomal)

The liposomal combination of cytarabine and daunorubicin is not given in the same doses or on the same schedule as other forms of cytarabine or daunorubicin. If you have used either of these medicines before, your dose schedule of cytarabine and daunorubicin liposomal may be different.

Your doctor will perform blood tests to make sure you do not have conditions that would prevent you from safely using cytarabine and daunorubicin.

Cytarabine and daunorubicin liposomal is given as an infusion into a vein. A healthcare provider will give you this injection.

This medicine must be given slowly, and the infusion can take at least 90 minutes to complete.

Tell your caregivers if you feel any burning, pain, or swelling around the IV needle when the medicine is injected.

Cytarabine and daunorubicin liposomal is usually given every other day for up to 3 infusions in a 5-day treatment cycle. If you need additional treatment cycles, you will need to wait 5 to 8 weeks before you receive the medicine again.

You may be given other medications to help prevent serious side effects or allergic reaction. Keep taking these medicines for as long as your doctor has prescribed.

Cytarabine and daunorubicin liposomal doses are based on body surface area (height and weight). Your dose needs may change if you gain or lose weight or if you are still growing.

Your doctor will determine how long to treat you with this medicine.

This medicine can make it easier for you to bleed. Contact your doctor or seek emergency medical attention if you have easy bruising, unusual bleeding, or any bleeding that will not stop.

Detailed Cytarabine liposomal / daunorubicin liposomal dosage information

Cytarabine and daunorubicin (liposomal) Dosage information (more detail)

What happens if I miss a dose?

Call your doctor for instructions if you miss an appointment for your cytarabine and daunorubicin liposomal injection.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while using Cytarabine and daunorubicin (liposomal)?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

Cytarabine and daunorubicin (liposomal) side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Cytarabine and daunorubicin liposomal can make it easier for you to bleed. Call your doctor or seek emergency medical attention if you have:

• easy bruising, unusual bleeding (nose, mouth, vagina, rectum), or any bleeding that will not stop;

• signs of bleeding in your digestive tract--feeling very weak or dizzy, severe stomach pain, black or bloody stools, coughing up blood or vomit that looks like coffee grounds; or

• signs of bleeding in the brain--sudden numbness or weakness (especially on one side of the body), sudden severe headache, problems with vision or balance.

Cytarabine and daunorubicin may cause serious side effects. Call your doctor at once if you have:

• severe or ongoing diarrhea;

• sores or white patches in or around your mouth, trouble swallowing or talking, dry mouth, bad breath, altered sense of taste;

• fast, slow, or uneven heart rate;

• pain, burning, irritation, or skin changes where the injection was given;

• heart problems--swelling, rapid weight gain, feeling short of breath; or

• signs of infection--fever, chills, swollen gums, skin sores, cold or flu symptoms, cough with mucus, chest pain, wheezing, trouble breathing, rapid heart rate, fainting.

Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.

Common side effects of cytarabine and daunorubicin may include:

• bleeding (especially nosebleeds);

• fever, chills;

• irregular heartbeats;

• nausea, vomiting, stomach pain, loss of appetite;

• diarrhea, constipation;

• mouth sores;

• cough, trouble breathing;

• rash;

• muscle or joint pain;

• headache, feeling tired;

• swelling anywhere in your body; or

• sleep problems (insomnia).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See more: Cytarabine and daunorubicin (liposomal) Side Effects

What other drugs will affect Cytarabine and daunorubicin (liposomal)?

Other drugs may affect cytarabine and daunorubicin liposomal, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Source: https://themeditary.com/drug/cytarabine-and-daunorubicin-liposomal-6049.html?utm_source=blogger_source&utm_medium=blogger_medium&utm_campaign=blogger_cam

Drug Class: Antineoplastic combinations

Post by: TheMediTary.Com